Oncogenic IDH mutations increase heterochromatin-related replication stress without impacting tumor mutation burden

Authors

Schvartzman, Juan-Manuel

Koche, Richard Patrick

Thompson, Craig B.

Description

Summary from GEO: "Oncogenic mutations in the metabolic enzyme isocitrate dehydrogenase 1 and 2 (IDH1/2) have been found in a number of liquid and solid tumors. Their pathogenic mechanism of action involves production of 2-hydroxyglutarate (2HG), an oncometabolite that acts in part by inhibiting members of a family of dioxygenases that modulate chromatin dynamics. Recent work has suggested that mutant...

Subject

DNA Replication

Heterochromatin

Isocitrate Dehydrogenase

Poly ADP Ribosylation

Poly(ADP-ribose) Polymerase Inhibitors

Access Rights

Free to All